Combs Spouts Off

"It's my opinion and it's very true."

  • Calendar

    March 2007
    S M T W T F S
     123
    45678910
    11121314151617
    18192021222324
    25262728293031
  • Recent Posts

  • Tag Cloud

  • Archives

Archive for March, 2007

Essjay scandal

Posted by Richard on March 6, 2007

I like Wikipedia, use it, and consider it a valuable online resource. But I’ve always remained aware of its limitations and appropriately (IMHO) cautious about relying solely on it as a source of information. I’m not as skeptical as some people — such as this contributor to the Techwr-l list:

Did you really say Wikipedia? 😉 It’s like a classroom without a teacher… fun, but no authority.
— Johan Hiemstra

I think that was a bit harsh. Funny, but harsh. But Hiemstra’s skepticism is certainly vindicated by stories like this one:

In a blink, the wisdom of the crowd became the fury of the crowd. In the last few days, contributors to Wikipedia, the popular online encyclopedia, have turned against one of their own who was found to have created an elaborate false identity.

Under the name Essjay, the contributor edited thousands of Wikipedia articles and was once one of the few people with the authority to deal with vandalism and to arbitrate disputes between authors.

To the Wikipedia world, Essjay was a tenured professor of religion at a private university with expertise in canon law, according to his user profile. But in fact, Essjay is a 24-year-old named Ryan Jordan, who attended a number of colleges in Kentucky and lives outside Louisville.

Mr. Jordan contended that he resorted to a fictional persona to protect himself from bad actors who might be angered by his administrative role at Wikipedia. (He did not respond to an e-mail message, nor to messages conveyed by the Wikipedia office.)

The Essjay episode underlines some of the perils of collaborative efforts like Wikipedia that rely on many contributors acting in good faith, often anonymously and through self-designated user names. But it also shows how the transparency of the Wikipedia process — all editing of entries is marked and saved — allows readers to react to suspected fraud.

Nothing better illustrates the flip side — the transparency and its benefits — than this Wikipedia entry about the scandal. Note, however, that the entry is itself embroiled in controversy. Interesting idea, this Wikipedia.
 

Subscribe To Site:

Posted in Uncategorized | Tagged: , , , | Leave a Comment »

Health news updates

Posted by Richard on March 6, 2007

Back in September, I warned you to start taking vitamin D supplements as the days grew short. I hope you did, and I hope it helped you avoid the flu this winter. The February issue of Life Extension Magazine (yes, I’m a bit behind in my reading) has an article that goes into much greater depth regarding the connection between seasonally low levels of vitamin D and high rates of influenza. It includes information about how vitamin D helps protect you:

In the past few years, several independent researchers have shown that vitamin D significantly enhances the genetic expression of antimicrobial peptides in human monocytes (precursors to macrophages), neutrophils, and other immune system cells.15,1617-19

For Dr. Cannell, these various clues led to one inescapable conclusion: vitamin D—which is produced when the skin is exposed to summer sunlight, and which, conversely, declines in winter—plays a critical role in our vulnerability to influenza infection. In fact, vitamin D must surely be Hope-Simpson’s mysterious “seasonal stimulus.” Dr. Cannell consulted a number of leading vitamin D researchers, all of whom agreed with his conclusions. They include researchers from such venerable institutions as the National Institutes of Health and the Harvard School of Public Health. One of these scientists, Dr. Michael F. Holick, has been studying vitamin D for three decades.1,7,20

In an interview with Life Extension, Dr. Holick alluded to the special relationship between vitamin D and the body’s primary immune system defenders, the macrophages. “What intrigues me the most,” Dr. Holick noted, “is that we’ve always known that macrophages activate vitamin D.” The form of vitamin D generated through the skin’s interaction with ultraviolet B radiation (from sunshine or artificial sources) is a pre-hormone. It must be converted in the body to its active hormone form, called 1,25-dihydroxyvitamin D3. An intermediary form, known as 25-hydroxyvitamin D, is the major circulating form of vitamin D, and is measured to determine vitamin D status.20

Most of this activation of vitamin D occurs in the liver and kidneys. However, the fact that macrophages facilitate the conversion of circulating vitamin D to its active form,20 and that activated vitamin D in turn regulates the activity of macrophages, suggests an important relationship between the two. These antimicrobial proteins help to destroy invading infectious microbes. With their broad-spectrum activity, they are capable of killing everything from bacteria to viruses. They have been shown to be an important part of the respiratory tract’s defense against invaders, and likewise show promise in fighting the influenza virus.

Life Extension Foundation has also taken aim at the shoddy supplement study I wrote about last week, issuing a consumer alert entitled "Another Flawed Attack against Antioxidants." Among other issues, LEF looked at the ridiculously wide range of nutrient dosages in the studies:

The JAMA review that attacked the value of antioxidants included vitamins A, C, E, and selenium and evaluated these very basic nutrients in a very wide & inconsistent dosage range:

Supplement

Dose range

Vitamin A (synthetic)

1,333200,000*** IU

Alpha Tocopherol (synthetic)

105,000 IU

Vitamin C (synthetic)

60 – 2,000 mg

Selenium (natural)

20 – 200 mcg

As an example of the strange decisions made by the JAMA authors as to which studies to exclude or include in their analysis, they selected a single dose study*** of patients using 200,000 IU of vitamin A, who were subsequently followed for 3 months.8

LEF also found that the authors misrepresented some of the included studies, attributing deaths that didn’t happen, and seem to have intentionally omitted a long list of studies that demonstrated positive benefits from antioxidants from their cherry-picked (68 out of 815) sample. LEF characterized the JAMA study as an "irrational and highly biased attack," and quoted several other respected scientists who dismissed this study as deeply flawed.
 

Subscribe To Site:

Posted in Uncategorized | Tagged: , , , , | Leave a Comment »

Lancet study looks more and more bogus

Posted by Richard on March 5, 2007

Remember the Johns Hopkins study published in Lancet last October? The researchers claimed that our invasion of Iraq had led to more than 650,000 "excess" deaths (one in 40 Iraqis) since March 2003. I thought the number was absurd and suspected fraud for political purposes. Quite a few bloggers looked at the study and found it wanting, as did the Prez. But defenders argued that we critics simply lacked the in-depth knowledge of statistics needed to understand the sophisticated methodology employed.

Well, according to The Times of London, a number of people who do have an in-depth knowledge of statistics don’t think much of the study, either (emphasis added):

The controversy has deepened rather than evaporated. Several academics have tried to find out how the Lancet study was conducted; none regards their queries as having been addressed satisfactorily. Researchers contacted by The Times talk of unreturned e-mails or phone calls, or of being sent information that raises fresh doubts.

“The authors ignore contrary evidence, cherry-pick and manipulate supporting evidence and evade inconvenient questions,” contends Professor Spagat, who believes the paper was poorly reviewed. “They published a sampling methodology that can overestimate deaths by a wide margin but respond to criticism by claiming that they did not actually follow the procedures that they stated.” The paper had “no scientific standing”. Did he rule out the possibility of fraud? “No.”

Some of the information about how the survey was conducted was new to me. Burnham, Roberts, et al — the Johns Hopkins "researchers" — never set foot in Iraq, did no research themselves, and apparently can’t actually vouch for how the survey was conducted:

They drafted in Professor Riyadh Lafta, at Al Mustansiriya University in Baghdad, as a co-author of the Lancet paper. Professor Lafta supervised eight doctors in 47 different towns across the country. In each town, says the paper, a main street was randomly selected, and a residential street crossing that main street was picked at random.

The doctors knocked on doors and asked residents how many people in that household had died. … Out of 1,849 households contacted, only 15 refused to participate.

A claimed participation rate of over 99%? Gee, there’s nothing suspicious about that!

One of the critics of the study is a former associate, Dr. Richard Garfield. Of course, his complaint seems to be that there was underreporting:

Together with Professor Hans Rosling and Dr Johan Von Schreeb at the Karolinska Institute in Stockholm, Dr Garfield wrote to The Lancet to insist there must be a “substantial reporting error” because Burnham et al suggest that child deaths had dropped by two thirds since the invasion. The idea that war prevents children dying, Dr Garfield implies, points to something amiss.

Professor Rosling was one of several academics who complained about stonewalling:

Professor Rosling says that, despite e-mails, “the authors haven’t provided us with the information needed to validate what they did”. He would like to see a live blog set up for the authors and their critics so that the matter can be clarified.

Another critic is Dr Madelyn Hsaio-Rei Hicks, of the Institute of Psychiatry in London, who specialises in surveying communities in conflict. In her letter to The Lancet, she pointed out that it was unfeasible for the Iraqi interviewing team to have covered 40 households in a day, as claimed. She wrote: “Assuming continuous interviewing for ten hours despite 55C heat, this allows 15 minutes per interview, including walking between households, obtaining informed consent and death certificates.”

I’d say that Hicks has totally destroyed the credibility of this study with one simple little calculation involving only the most basic math. No advanced statistics knowledge required.

Does she think the interviews were done at all? Dr Hicks responds: “I’m sure some interviews have been done but until they can prove it I don’t see how they could have done the study in the way they describe.”

Professor Burnham says the doctors worked in pairs and that interviews “took about 20 minutes”. The journal Nature, however, alleged last week that one of the Iraqi interviewers contradicts this. Dr Hicks says: : “I have started to suspect that they [the American researchers] don’t actually know what the interviewing team did. The fact that they can’t rattle off basic information suggests they either don’t know or they don’t care.”  

Burnham told The Times he had "“full confidence in Professor Lafta and full faith in his interviewers.” Well, that settles it. No need to wonder about how those interviews were done. No need to validate the data or clarify the methodology.

Dr. Burnham has assured us that he has "full faith." That’s how they’re doing science at Johns Hopkins these days.
 

Subscribe To Site:

Posted in Uncategorized | Tagged: , , | Leave a Comment »

Decline of hip-hop?

Posted by Richard on March 2, 2007

As regular readers know, I’m not religious. But this is the kind of story that makes even me whisper, "Please, God, let it be true":

Maybe it was the umpteenth coke-dealing anthem or soft-porn music video. Perhaps it was the preening antics that some call reminiscent of Stepin Fetchit.

The turning point is hard to pinpoint. But after 30 years of growing popularity, rap music is now struggling with an alarming sales decline and growing criticism from within about the culture’s negative effect on society.

Rap insider Chuck Creekmur, who runs the leading Web site Allhiphop.com, says he got a message from a friend recently "asking me to hook her up with some Red Hot Chili Peppers because she said she’s through with rap. A lot of people are sick of rap … the negativity is just over the top now."

The rapper Nas, considered one of the greats, challenged the condition of the art form when he titled his latest album "Hip-Hop is Dead." It’s at least ailing, according to recent statistics: Though music sales are down overall, rap sales slid a whopping 21 percent from 2005 to 2006, and for the first time in 12 years no rap album was among the top 10 sellers of the year. A recent study by the Black Youth Project showed a majority of youth think rap has too many violent images. In a poll of black Americans by The Associated Press and AOL-Black Voices last year, 50 percent of respondents said hip-hop was a negative force in American society.

Read the whole thing — it’s an interesting and multifaceted story.

For me, it’s not just the misogyny, glorification of violence, thuggishness, and nihilism that turn me off to hip-hop. Over the last 35 or 40 years, I’ve liked plenty of music that had a message I fundamentally disagreed with. But I’ve liked the music. Heck, there are rock and roll songs that I really like even though I have no idea what they’re about. They just sound nice.

I heard someone on the radio once discussing music, and he said music consisted of three elements: melody (which comes from the head), harmony (which comes from the heart), and rhythm (which comes from the groin).

I don’t know if that’s true or not, but if it is, it explains my dislike of hip-hop. Hip-hop discards the first two elements completely and presents only a vile message packaged in rhythm alone. To me, that’s not just anti-intellectual, but anti-human. It’s the glorification and celebration of the animalistic.

Melody matters a lot to me. Melody is what makes music music. The absence of melody — the rejection of melody — turns me off. Heck, it annoys me. Hell, it angers me. If you call yourself a "musician," but you can’t — or won’t — write a melody, I hope you, your do-rag, and your hate-filled doggerel go back to working at the Grease Monkey where you belong.

And did I mention that I have no use for "singers" who can merely chant?
 

Subscribe To Site:

Posted in Uncategorized | Tagged: , , | 9 Comments »

Another shoddy supplement study

Posted by Richard on March 1, 2007

Last March, I commented on several shoddy studies of nutritional supplements, singling out a calcium / vitamin D study that Life Extension Foundation’s Bill Faloon described as perhaps "one of the most poorly designed studies in the history of modern medicine." Well, the February 28 issue of the Journal of the American Medical Association (JAMA) reports a "meta-analysis" of antioxidants that has to rank pretty high on the list of bogus studies. It purports to demonstrate that there is no health benefit associated with vitamins A, C, and E, beta carotene, and selenium, and that A and E may "significantly increase mortality."

The Linus Pauling Institute at Oregon State University was quick to criticize the study. Its director, Balz Frei, said the meta-analysis had multiple serious flaws:

“This is a flawed analysis of flawed data, and it does little to help us understand the real health effects of antioxidants, whether beneficial or otherwise,” Frei said.

The “meta-analysis” published in JAMA, which is a statistical analysis of previously published data, looked at 815 antioxidant trials but included only 68 of them in its analysis, Frei said. And two of the studies excluded – which were published in the Journal of the National Cancer Institute and the prominent British medical journal Lancet – found substantial benefits and reduced mortality from intake of antioxidant supplements.

It’s not as if the researchers conducting this meta-analysis carefully selected the best, most unambiguous 68 trials out of the 815 they considered. Instead, they picked mainly various clinical trials of subjects with existing health problems. Furthermore, these sick subjects were getting a variety of pharmaceutical drugs, other nutrients, or other treatments, thus making any conclusions about the specific nutrients being "meta-analyzed" ambiguous and suspect.

The Council for Responsible Nutrition argued that this study represents a misuse of meta-analysis (emphasis added):

"Healthy consumers can feel confident in continuing to take antioxidants for the benefits they provide. This meta-analysis does nothing to change those facts," said CRN’s Andrew Shao, Ph.D., vice president, scientific and regulatory affairs. "While meta-analyses can be useful when the included studies are very similar in design and study population, this meta-analysis combined studies that differ vastly from each other in a number of important ways that compromise the results."

For example, the meta-analysis included clinical trials that varied widely in terms of dosage, duration, study population and nutrients tested — such as data from a one-day study with a vitamin A dose of 200,000 IU mixed with data from other studies lasting years.

200,000 IU of Vitamin A?? According to the NIH Office of Dietary Supplements, the "Tolerable Upper Intake Level" of retinol (vitamin A) is 10,000 IU.

"Moreover, the overwhelming majority of the clinical trials included in the meta-analysis tested for secondary prevention, looking at how a nutrient works in those who already are diseased, instead of primary prevention studies in healthy populations.

"Combining secondary prevention and primary prevention trials and then making conclusions for the entire population is an unsound scientific approach," said Dr. Shao. "Additionally, many of the treatment trials had limitations, including the expectation that a simple antioxidant vitamin could be expected to overturn serious illness, such as cancer or heart disease. These trials likely statistically skewed the results."

When it comes to studying nutrients, herbs, and the like, the methodology favored by many mainstream medical researchers seems to be something like this: Give a bunch of people who have, say, heart disease some supplement. If lots of them die, announce that taking the supplement can kill you. If lots of them get well, caution the public that further study is needed. Meanwhile, try to come up with a chemical analogue of the supplement that works about the same, but can be patented and sold as a prescription drug.
 

Subscribe To Site:

Posted in Uncategorized | Tagged: , , , | Leave a Comment »